Differences: N-acetylcysteine is formulated as both IV or inhalation solutions, whereas the effervescent formulation (brand name Legubeti, FDA approved Feb 2024) is given as an oral solution. According to the prescribing information, Legubeti active ingredient is actually acetylcysteine lysine, but is still dosed based on acetylcysteine. Dosing is technically not an exact conversation (4.74 g of acetylcysteine lysine = 2.5 g acetylcysteine), however, clinically, we are always dosing based on acetylcysteine. It appears to be manufactured in two strengths 500mg and 2.5 g (acetylcysteine content).

Tldr: nac or acetylcysteine lysine —>convert to acetylcysteine. We always dose based on acetylcysteine. The effervescent is specifically formulated for PO administration and indicated for acetaminophen OD.

Bupropion is a NDRI. Then you would have to add on an SSRI. However, 2 antidepressants aren’t usually prescribed together.

Edit: dextromethorphan/bupropion (brand name Auvelity). The dextromethorphan hits multiple targets including NMDA and sigma 1, but technically has some inhibition activity to SERT. I am unsure how strong that activity is, whether it is dose dependant, if its an active metabolite etc. Also should point out that nowhere on the manufacturers website do they talk about using the dextromethorphan to hit serotonin. According to the website, the true mechanism of action of Auvelity for treating MDD is not well understood.

Edit2: check out this page. Gives more info and some references. Apparently fairly strong against SERT. [(https://tmedweb.tulane.edu/pharmwiki/doku.php/dextromethorphan)]

https://theneedledrop.com/ check out the reviews and the loved list. Also, I’ll Shazam songs I like and look them up later.

Hi, pharmacist here. I wanted to clarify that the “discontinuation” you saw on the FDA website regarding sertraline does not mean the drug has been taken off the market. It simply indicates that one manufacturer—Strides Pharma Inc.—has recently stopped producing all strengths of sertraline tablets (25 mg, 50 mg, and 100 mg).

Sertraline is a widely used generic medication, and many other manufacturers continue to produce it.

Pokemon Blue on Gameboy

Dave Stewart covering Zombie by The Cranberries https://youtu.be/1iDTYnxCNXM

I just let Bitwarden chose my username lol

Lol ya and all that video footage is owned by the company of those cameras, like Ring aka Amazon. They can access it at anytime and they can even give it to the police.

Edit: there are setups in which you can store your footage on your own drives. However, many people don’t know how to set it up so they use out of the box camera + app which stores all the data on the company servers.

[Rhubarb] Aphex Twin

Milf manor

Guild Wars (the original) Just so nostalgic to me. Gameplay is fun even after all these years.

Don’t do it

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